NAFLD Fibrosis Score (NFS, Non-Alcoholic Fatty Liver Disease)
NAFLD fibrosis score (NFS) =
-1.675 + (0.037 × age[years])
+ (0.094 × BMI[kg/m²])
+ (1.13 x IFG or diabetes[yes=1,no=0])
+ (0.99 × AST / ALT ratio)
– (0.013 × PLT[×109/L])
– (0.66 × albumin[g/dL])
키 (cm) :
체중 (kg) :
Age (나이, year) :
AST (U/L) :
ALT (U/L) :
Albumin (g/dL) :
Platelet (109/L = 103/㎕) :
*Platelet 단위 주의 : Platelet 개수 230,000/㎕ 이라면 ‘230’만 입력
(Platelet 정상 참고치 : 약 130,000/㎕ ~ 440,000/㎕)
NAFLD Score and Correlated Fibrosis Severity
NFS ＜ -1.455 : Predictor of absence of significant fibrosis (F0-F2), negative predictive value 93%
NFS -1.455 ~ 0.675 Indeterminant score
NFS ＞ 0.675 : Predictor of presence of significant fibrosis (F3-F4), positive predictive value of 90%
F0 : no fibrosis
F1 : mild fibrosis
F2 : moderate fibrosis
F3 : severe fibrosis
F4 : cirrhosis
Reference :
Angulo P, Hui JM, Marchesini G, Bugianesi E, George J, Farrell GC, Enders F, Saksena S, Burt AD, Bida JP, Lindor K, Sanderson SO, Lenzi M, Adams LA, Kench J, Therneau TM, Day CP. The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD. Hepatology. 2007 Apr;45(4):846-54. doi: 10.1002/hep.21496. PMID: 17393509.
