AST to Platelet Ratio Index (APRI) 계산기
APRI = ((AST level / AST ULN) / PLT[×109/L]) × 100
Serum AST (U/L) :
ULN of AST (U/L) :
※ ULN : Upper Limit of Normal
Platelet (109/L = 103/㎕) :
*Platelet 단위 주의 : Platelet 개수 230,000/㎕ 이라면 ‘230’만 입력
(Platelet 정상 참고치 : 약 130,000/㎕ ~ 440,000/㎕)
APRI Score
APRI > 0.7 : Predicting significant fibrosis (≥F2) – sensitivity 77%, specificity 72%
APRI > 1.0 : Predicting severe fibrosis (≥F3) – sensitivity 61%, specificity 64%
APRI > 1.0 : Predicting cirrhosis (F4) – sensitivity 76%, specificity 72%
Reference :
Wai CT, Greenson JK, Fontana RJ, Kalbfleisch JD, Marrero JA, Conjeevaram HS, Lok AS. A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C. Hepatology. 2003 Aug;38(2):518-26. doi: 10.1053/jhep.2003.50346. PMID: 12883497.
Lin ZH, Xin YN, Dong QJ, Wang Q, Jiang XJ, Zhan SH, Sun Y, Xuan SY. Performance of the aspartate aminotransferase-to-platelet ratio index for the staging of hepatitis C–related fibrosis: An updated meta-analysis. Hepatology. 2011 Mar;53(3):726–736. doi: 10.1002/hep.24105. PMID: 21319189.